NSW Police are targeting speeding, mobile phone, seat belt and motorcycle/helmet offences this long weekend, June 8-10.
The police said offending drivers could expect double demerit points.
They said many people were expected to head south for the start of the snow season and reminded drivers not to try and do too much driving in a short time frame.
165 people had lost their lives in NSW since the start of the year.
In Mystery Bay on June 5, a 45-year-old man lost his life after his car crashed into a tree.
Police said drivers needed to be more aware of their surroundings and "drive to survive".
Traffic and Highway Patrol Commander Assistant Commissioner Michael Corboy said the majority of those who had lost their lives this year in NSW were men.
"Speeding or drink driving doesn't make you more of a man - nor does risking the life of your mates or those you love," Assistant Commissioner Corboy said.
"I am renewing our appeal to passengers, regardless of where you are sitting in the vehicle, to call the driver out on their behaviour."
Minister for Police and Emergency Services David Elliott said the police were not interested in excuses when it came to ensuring the safety of everyone on the road.
"Drivers need to be vigilant, tragedy can strike anywhere, at any time," Mr Elliott said.
"Don't become insulated in your own invincibility, be alert and remain mindful of drivers around you - drive to survive.
"Many people are expected to leave Sydney and head south for the start of the snow season.
"People are reminded not to try and do too much in a short time frame, placing themselves and their loved ones at risk of being killed or injured in a crash."
Minister for Roads Andrew Constance said too many people became complacent when they got into a vehicle.
"Too many people have lost their lives or have been injured on our roads so far this year," Mr Constance said.
"Speeding, drink and drug driving and fatigue remain the biggest killers on our roads.
"We need everyone to think about their actions every time they get behind the wheel and the impact those actions may have on others."
Operation Stay Alert, the state's June long-weekend road safety operation, will start at 12.01am on Friday 7 June 2019 and will run until 11.59am on Monday 10 June 2019.
During Operation Stay Alert 2018, three people lost their lives in separate crashes on NSW roads.