As such, this weekend's round 21 games, inside the Queensland hub, could prove pivotal for a number of NRL club's finals chances.

Spearheading a number of those finals aspirations will be South Coast talents, starting with Thursday's game between the Knights and Broncos at Suncorp Stadium.

Newcastle's side is coached by former Batemans Bay Tiger Adam O'Brien while Moruya's Rhys Kennedy will start on the bench for the Broncos.

On Friday, the Raiders battle the Dragons, whose side features Gerringong duo Tariq Sims and Jackson Ford as well as Albion Park-Oak Flats' Adam Clune.

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That will be the first of the Cbus Super Stadium double-header, followed by the Eels and Rabbitohs' fixture.

Batemans Bay's Brad Arthur is the coach of Parramatta, with Nowra-born Cody Walker starting at six for the Bunnies.

The first of Saturday's match pits the Warriors against the Sharks, with the former's side featuring Shellharbour's Euan Aitken and Milton-Ulladulla's Jack Murchie.

The latter's side contains lock forward Jack Williams, who was born in Pambula.

Up next is the Roosters and Panthers, with Park's Drew Hutchison named at five-eighth for the tri-colours - with Kiama's Josh Morris ruled out with a hamstring injury.

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The final match of the day sees the blockbuster between the Sea Eagles and Storm, who are going for the 17th straight win.

Gerringong's Reuben Garrick will start on the win for Manly-Warringah, with Bega's Dale Finucane and former Shellharbour Shark Chris Lewis in Melbourne's forward pack.

On Sunday, Tathra's Adam Elliot and his Bulldogs lock horns with the Tigers at Cbus Super Stadium

The final match will see the Titans, coached by Milton's Justin Holbrook and featuring Kiama's Mitch Rein at nine, go toe-to-toe with the Cowboys.