New data released by the federal government shows the Southern Highlands and Shoalhaven is ranked second in the state in vaccine take up just behind the North Sydney and Hornsby area.
In the Southern Highlands and Shoalhaven region, 50.5 per cent of people aged 15 and over had received their first jab compared to 51.9 per cent in North Sydney and Hornsby.
And 22 per cent of those over 15 in the Southern Highlands were fully vaccinated, almost 5 percentage points less than North Sydney and Hornsby.
In the capital region, which holds the Far South Coast and sits between the Shoalhaven, the ACT and the Victorian border, 46.8 per cent of people aged 15 and over had received at least one dose and 17.9 per cent had received both doses.
South West Sydney, which is the worst area impacted by the virus, was ranked last in NSW with 33.1 per cent of its population having been given their first dose while only 14.6 per cent were fully vaccinated.
The data did not show the average age of people in an area or the supply rates of vaccines which may have caused rankings to skew in favour of areas with a higher percentage of people who had been eligible for the vaccination.
Over 12 and a half million vaccine doses had been administered in the country with over one and a half million coming from NSW state administered clinics and about seven million coming from commonwealth clinics.
The state recorded 233 new cases on Wednesday with Premier Gladys Berejiklian announcing a man in his 20s had died in his home from the virus.
The Premier has maintained 80 per cent of the adult population in NSW would need to be vaccinated for there to be no more lockdowns.
"It's really in our hands how we deal with the cases coming down, but also vaccinations," Ms Berejiklian said.
"Both vaccines are working very effectively. We still don't know of anyone in intensive care who has received both doses."
The Prime Minister on Friday announced Australia would need to fully vaccinate 70 per cent of its eligible population before restrictions begin to ease. The next phase, essentially eradicating lockdowns, would kick in at 80 per cent.
Federal opposition leader Anthony Albanese wants to pay $300 to every Australian who is fully vaccinated by December 1.
Labor on Monday called for $300 to be paid directly to any Australian over 18 fully-vaccinated by December 1.
Prime Minister Scott Morrison blasted the move as a "vote of no-confidence" in Australians.
With Finn McHugh and Natalie Croxon
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