Director of Medical Services Caroline Phegan was the first to get the jab with about 40 of her staff to also receive a dose on Friday.

"I know how important it is to vaccinate against a disease like COVID-19 and the rollout of this vaccine is just another way we as healthcare workers can protect ourselves, our loved ones and those most vulnerable," Dr Phegan said.

"As a doctor working in regional hospitals, you need to be prepared for anything.

"We have had suspected COVID-19 cases come through our emergency department here in Murray Bridge, and it's just so important that we are vaccinated to prevent any potential spread among the local community."

Premier Steven Marshall said SA's response to the pandemic has been world-leading and Friday marked another milestone in administering the nation's first AstraZeneca vaccines.

"Barely 36 hours after the vaccines arrived in South Australia, our public health team have safely transported 1000 doses, brought this regional clinic online, and are ready to begin vaccinating our frontline staff," he said.

"We have taken our state's biggest ever peacetime operation to the next stage and are determined to provide the opportunity for every South Australian to be vaccinated by the end of the year."

Health Minister Stephen Wade said the expansion of the vaccination rollout to regional areas was an important step towards protecting the whole of South Australia.

"Starting vaccinations in Murray Bridge today is the next step in the vital vaccine rollout, reaching more of our regional based healthcare and quarantine and border workers," he said.

More vaccine hubs at the Riverland General Hospital in Berri, Mount Gambier Hospital, Whyalla Hospital, Port Pirie Hospital and Port Augusta Hospital are expected to come online as the program continues.

Smaller vaccine clinics will also be established throughout the state during each phase of the rollout.

Australian Associated Press